ACTIVE GRANTS

START is an international randomized trial that determined whether starting antiretroviral therapy (ART) early (before CD4 drops to less than 500 cells/mm³), rather than waiting until CD4 drops to less than 350 cells/mm³. The aim is to assess if there are continued differences in clinical outcomes between the two groups.

The study aims to investigate strategies for preventing new infections and reducing transmission of HIV among men who have sex with men (MSM) in Nigeria. This study is investigating the use of Treatment as Prevention (TasP) and Pre-exposure Prophylaxis (PreP) preventions. Key findings so far: An association between higher engagement in TasP with disclosure of sexual orientation to health care providers. Also documenting patterns of transmission and trends over time in Nigeria.

Intervention arms: Peer Transition Advocates (PTAs) vs Education Interventionists (EIs) To measure successful transition and viral suppression in ALHIV transitioned to adult clinic.

To recruit 200 participants in 2 years. The trial aims to compare:
dolutegravir with pharmaco-enhanced darunavir versus dolutegravir with predetermined nucleosides versus recommended standard of care antiretroviral regimens in patients with HIV infection who have failed recommended first line therapy (the D2EFT study)

To upgrade laboratory infrastructure and functions to international standards to support H3Africa investigators in Africa. The bio-repository supports multiple H3Africa investigators to conduct high quality genomics and translational research in Africa using well processed, preserved and quality controlled and protected human biological samples. To be accessible to the H3Africa and larger research community to address health issues and diseases affecting the African continent.

The study is a two-arm cluster randomized controlled trial that includes unsuppressed children living with HIV (0-10 years old) and their caregivers at six cluster sites in Nigeria. It will explore facilitators and barriers to ART adherence among young children to develop a caregiver peer mentor training curriculum and interventional programme, and also test the impact of caregiver peer support, a locally adapted behavioural intervention, to improve adherence and promote achievement of viral suppression among children.

This study investigates how breast milk microbiota affects the growth and the ability to respond to childhood vaccinations in HIV exposed but uninfected infants.

The project uses data from population based cancer registries (PBCR) to study the epidemiological factors associated with incident breast cancer and molecular subtypes. It also aims to research on genome wide association study (GWAS) of breast cancer in general and of molecular subtypes of breast cancer in indigenous Nigerian women.

The study seeks to utilize simple technological support in dealing with a complex and significant problem- delays to diagnosis in breast cancer. The BRIDGE App is a simple, innovative, clinic-based m-health patient referral service used by trained Community Health Workers (CHWs), in rural settings to promote early detection and reduce delays to diagnosis of breast cancer in Nigeria.

The ISN-NCD study is a 2-year study sponsored by ISN Products Nig. Ltd. This study seeks to estimate the burden and progression of non-communicable diseases (NCDs) including hypertension, diabetes, prostate and cervical cancer, and chronic obstructive pulmonary diseases among persons living with HIV. 2

Developing a Pharmacovigilance system in Four African countries